Just Do the 12-Lead: How Sneaky Cardiac Calls Can Fool You


There’s a moment that lives rent-free in my brain: a patient, mid-60s, pale and diaphoretic, insisting their only complaint is “a little indigestion.” No chest pain, no radiation, nothing textbook. My gut said something was off, so I slapped on a 12-lead.

STEMI. Right there, plain as day.

That moment taught me a lesson I’ll never forget: when in doubt, just do the 12-lead.


We train for the “classic” presentation—substernal chest pain, radiating to the left arm, nausea, diaphoresis. And yes, sometimes it really is that clean.

But often, it isn’t.

Cardiac problems can show up as:

  • Epigastric discomfort
  • Fatigue or generalized weakness
  • Shortness of breath without chest pain
  • Syncope or near-syncope
  • Jaw, neck, or back pain
  • Nausea or unexplained anxiety

And yes – sometimes event just a gut feeling that something isn’t right.


  1. Elderly PatientsTheir pain responses are often blunted, and they may not experience or express classic symptoms.
    • “I just feel off” might be their version of a full-blown MI.
  2. 2. Diabetics
    • Neuropathy can mask pain, and they may only present with weakness, dizziness, or vomiting.
  3. 3. Women
    • Studies continue to show that women are more likely to have atypical cardiac symptoms—and more likely to be misdiagnosed.

It takes less than 2 minutes. It costs nothing. It could change everything.

I’d rather run a dozen normal 12-leads than miss the one that matters. That strip could be the difference between a code in the driveway and a cath lab save.

So why do we hesitate?

Sometimes it’s pressure to move quickly. Sometimes it’s a partner or provider who minimizes the symptoms. Sometimes it’s just habit—we don’t expect the cardiac issue because the story doesn’t sound like one.

But the heart doesn’t care what we expect. It’ll sneak up on us anyway.


I’ve seen cardiac events hide behind vague complaints more times than I can count. The ones that still haunt me aren’t the screaming chest pains—they’re the “I almost didn’t call you” patients who looked stable but were crashing inside.

And yeah—every time I’ve trusted my gut and run the 12-lead “just in case,” I’ve never regretted it.


Pro Tips: Make the 12-Lead Your Reflex

  • Any chest pain = 12-lead
  • Any unexplained SOB or syncope = 12-lead
  • Any “something’s not right” feeling = 12-lead
  • Any patient over 50 with vague complaints = 12-lead
  • Any diabetic, elderly, or female patient with odd symptoms = 12-lead

Even better? Run serials. Get one early, and repeat en route if the story evolves. Subtle ST changes over time can be a game changer.


Cardiac calls are sneaky. Don’t let a clean story fool you. The patient isn’t lying—but their heart might be.

So next time you hesitate, hear this in your head:

Just do the 12-lead.

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